Background/Objectives: Dental caries is a widespread chronic infection, affecting a large segment of the population.Proximal caries, in particular, present a distinct obstacle for early identification owing to their position, which hinders clinical inspection.Radiographic assessments, particularly bitewing images (BRs), are frequently utilized to d
Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells
Regulatory T (Treg) cells maintain immune homeostasis by suppressing excessive immune responses.Treg cells induce tolerance against self- and foreign antigens, thus preventing autoimmunity, allergy, graft rejection, and fetus rejection during pregnancy.However, Treg cells also infiltrate into tumors and inhibit antitumor immune responses, thus inhi
Astrocyte-specific hypoxia-inducible factor 1 (HIF-1) does not disrupt the endothelial barrier during hypoxia in vitro
Abstract Background Astrocytes (AC) are essential for brain homeostasis.Much data suggests that AC support and protect the vascular endothelium, but increasing evidence indicates that during injury conditions they may lose their supportive role resulting in endothelial cell activation and BBB disturbance.Understanding the triggers that flip this sw
Injuries in children and general principles of management
Traumatic injuries and accidents are a major cause of morbidity and mortality in children worldwide, with traffic accidents causing the majority of Lotions deaths due to trauma.When possible, children with injuries should be cared for at a dedicated trauma center, as outcomes have been shown to improve with the care of a specialized trauma team.Gen